According to an article published on October 29, 2018 by American Academy of Ophthalmology Researchers from Taiwan have shown that people with type-2 diabetes who were treated with Metformin showed a significantly lower rate of age-related macular degeneration (AMD).The study further suggests that the anti-inflammatory and anti-oxidative effects of metformin can protect against AMD while also controlling diabetes. The research was presented at AAO 2018, the 122nd Annual Meeting of the American Academy of Ophthalmology.
It has been long known that inflammation and oxidative stress play a key role in the development of both diabetes and AMD. Since metformin suppresses inflammation and oxidative stress, researchers in Taiwan theorized that it was possible that the diabetes drug could also protect against AMD, one of the leading causes of blindness in Americans over age 50, currently affecting about 2.1 million people in the United States alone.
The researchers used the Taiwan National Health Insurance Research Database, to collect data on all patients recently diagnosed with type 2 diabetes from January 2001 to December 2013, dividing them into two groups: Those who took metformin (45,524 patients) and those who did not (22,681 patients). After following both groups for 13 years, the researchers found that patients in the metformin group had a significantly lower risk of developing AMD. In fact, half as many patients in the metformin group had AMD compared to the control group.
“Our study is the first to reveal the protective effect of metformin on the development of AMD,” said lead investigator, Yu-Yen Chen, M.D. “While more study is required to determine just how metformin protects against the development of AMD, this is an exciting development for patients at risk.”
AMD is a degenerative disease that happens when part of the retina called the macula is damaged. It’s the part of the eye that delivers sharp, central vision needed to see objects straight ahead. Over time, the loss of central vision can interfere with everyday activities, such as the ability to drive, read, and see faces clearly.
Diabetes is a complex disease that can result from, genetics, environment, lifestyle factors, such as smoking and diet, and involve systemic diseases like heart disease. How the diabetes develops is not fully understood, but researchers have shown that oxidative stress and inflammation play a critical role in the development and progression of AMD. Drusen formation, the earliest clinical finding, has been shown to result from a localized inflammatory response.
The research on Metformin provides a hope that blindness need not be an eventuality for most people afflicted with diabetes.
Read Original Article: https://www.sciencedaily.com/releases/2018/10/181029102836.htm